META-ANALYSIS ON THE EFFICACY OF STEM CELL THERAPY IN IMPROVING CARDIAC FUNCTION AFTER MYOCARDIAL INFARCTION: A REVIEW OF CLINICAL TRIALS ASSESSING THE IMPACT OF STEM CELLS ON MYOCARDIAL REHABILITATION

Abstract

Objectives: This study would involve systematically reviewing and analyzing data from clinical trials to evaluate the effectiveness of stem cell therapy in regenerating heart muscle and improving cardiac function after a heart attack. The analysis would focus on outcomes such as left ventricular ejection fraction (LVEF), myocardial viability, and overall survival rates.

Data Sources: Medline databases (PubMed, Medscape, Science Dir ect. EMF-Portal, google scholar).

Study Selection: The search results of the articles were screened by title and abstract then by full-text. The eligible full-text articles were downloaded to be utilized in further analytics procedures. Inclusion criteria were articles on the efficacy of stem cell therapy in improving cardiac function after myocardial infarction.

Data Extraction: If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, adequate information, and defined assessment measures.

Data Synthesis: Comparisons were made by structured review with the results tabulated.

Findings: 24 potentially relevant publications were included, and indicate that stem cell therapy reveals modest improvements in LVEF and significant reductions in left ventricular end-systolic and end-diastolic volumes with reducing mortality risk (OR 0.33) and reinfarction risk (OR 0.19)/ For heart failure-related rehospitalization, the odds ratio is 1.12, showing no clear effect. Potential reductions in target vessel revascularization (OR 0.62) and arrhythmia risk (OR 1.30) were also noted.

Conclusion: stem cell therapy may offer modest improvements in LVEF and significant reductions in left ventricular end-systolic and end-diastolic volumes. Additionally, there is a potential reduction in mortality and rehospitalization with reduced adverse effects following AMI.