SERUM FERRITIN LEVEL AS PROGNOSTIC BIOMARKERS IN PATIENTS WITH CONFIRMED COVID19 IN NORTHERN BORDERS PROVINCE

Authors

  • Muneera Abdullah Alnajdy, Jawahir Ali Y Sama, Mohammed Farhan Alenazi, Rakan Mohammed Bannunah, Ahmed Zayed Almutairi, Abdulelah Zayed Almutairi, Nouf Qasem Mohammed Albulayhishi, Essa Minaallah Al Mutairi, Mona Eid Al enazi, Abdulkarim Misfer Al Jabari, Wijdan Nasser Salem Al Ahmadi, Fahad Ismail Al Moteri, Ahmed M Aljohani, Abdulelah S Almoteri Author

Abstract

Background

Some COVID-19 patients have higher mortality and the responsible factors for this unfavorable outcome are still not well understood. Ferritin is a known inflammatory biomarker in COVID-19. However, many factors and co-morbidities can confound the level of serum ferritin. 

Objective

To study the association between ferritin levels at admission, representing an inflammatory state, and hospital mortality in COVID-19 patients.

Methods

From January through March 2022, COVID-19 positive patients with moderate to severe clinical symptoms were evaluated at admission, regarding clinical and laboratory data on hematologic parameters, C-reactive protein (8-10 mg/L), D-dimer (<500 µg/L), and cytomegalovirus co-infection. Patients were stratified based on ferritin levels (ferritin levels 24-336µg/L).

Results

A total of 506 patients were included; mean age = 46.56±16.15 years, 355 (70.15%) were male, and 151(29.85%) were female. Age, ferritin, C-reactive protein, and D-dimer were significantly associated with mortality. The magnitude of inflammation presents at the admission of COVID-19 patients, represented by high ferritin levels, is independently predictive of in-hospital mortality.

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Published

2024-12-26

Issue

Vol. 9 No. 2 (2024)

Section

Articles